|Application ||WB, E|
|Other Accession||P27117, NP_002530.1|
|Calculated MW||51148 Da|
|Antigen Region||323-352 aa|
|Other Names||Ornithine decarboxylase, ODC, ODC1|
|Target/Specificity||This ODC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-352 amino acids from the C-terminal region of human ODC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ODC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
Chaturvedi, R., et al. Gastroenterology 139(5):1686-1698(2010)
Zell, J.A., et al. J. Natl. Cancer Inst. 102(19):1513-1516(2010)
Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)
Hughes, D., et al. Colorectal Dis (2010) In press :
Grimminger, P.P., et al. Clin Lung Cancer 11(2):114-119(2010)
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