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ODC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P11926 |
| Other Accession | P27117, NP_002530.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51148 Da |
| Antigen Region | 323-352 aa |
| Gene ID | 4953 |
|---|---|
| Other Names | Ornithine decarboxylase, ODC, ODC1 |
| Target/Specificity | This ODC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-352 amino acids from the C-terminal region of human ODC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ODC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ODC1 |
|---|---|
| Function | Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
References
Chaturvedi, R., et al. Gastroenterology 139(5):1686-1698(2010)
Zell, J.A., et al. J. Natl. Cancer Inst. 102(19):1513-1516(2010)
Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)
Hughes, D., et al. Colorectal Dis (2010) In press :
Grimminger, P.P., et al. Clin Lung Cancer 11(2):114-119(2010)
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