|Application ||WB, E|
|Calculated MW||18864 Da|
|Antigen Region||1-30 aa|
|Other Names||Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, CD268, TNFRSF13C, BAFFR, BR3|
|Target/Specificity||This TNFRSF13C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TNFRSF13C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNFRSF13C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.|
|Cellular Location||Membrane; Single-pass type III membrane protein|
|Tissue Location||Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Mihalcik, S.A., et al. J. Immunol. 185(2):1045-1054(2010)
Parameswaran, R., et al. Cancer Res. 70(11):4346-4356(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Yuan, H., et al. DNA Cell Biol. 29(3):133-139(2010)
Yuan, H.X., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(2):111-114(2010)
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