|Application ||WB, E|
|Calculated MW||51295 Da|
|Antigen Region||283-311 aa|
|Other Names||GA-binding protein alpha chain, GABP subunit alpha, Nuclear respiratory factor 2 subunit alpha, Transcription factor E4TF1-60, GABPA, E4TF1A|
|Target/Specificity||This GABPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the Central region of human GABPA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GABPA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
Henderson, A.J., et al. Thorax 65(10):897-902(2010)
Eynon, N., et al. Physiol. Genomics 41(1):78-81(2010)
Levy, S., et al. IUBMB Life 62(3):237-246(2010)
Kim, Y.R., et al. J. Pathol. 220(4):446-451(2010)
Bruni, F., et al. J. Biol. Chem. 285(6):3939-3948(2010)
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