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KIF2C Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KIF2C Antibody (N-term) AP14043a
    KIF2C Antibody (N-term) (Cat. #AP14043a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the KIF2C antibody detected the KIF2C protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99661
Other Accession Q95LP1, NP_006836.2
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 81313 Da
Antigen Region 180-208 aa
Additional Information
Gene ID 11004
Other Names Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin, MCAK, KIF2C, KNSL6
Target/Specificity This KIF2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-208 amino acids from the N-terminal region of human KIF2C.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKIF2C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIF2C
Synonyms KNSL6
Function In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.
Cellular Location Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2.
Tissue Location Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.


Tanno, Y., et al. Genes Dev. 24(19):2169-2179(2010)
Gnjatic, S., et al. Int. J. Cancer 127(2):381-393(2010)
Sanhaji, M., et al. Mol. Cell. Biol. 30(11):2594-2607(2010)
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Kollu, S., et al. Curr. Biol. 19(24):2108-2113(2009)

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$ 295.00
$ 99.00
Cat# AP14043a
(40 western blots)
Availability: In Stock
Bulk Size
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