|Application ||WB, E|
|Other Accession||Q95LP1, NP_006836.2|
|Calculated MW||81313 Da|
|Antigen Region||180-208 aa|
|Other Names||Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin, MCAK, KIF2C, KNSL6|
|Target/Specificity||This KIF2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-208 amino acids from the N-terminal region of human KIF2C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIF2C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.|
|Cellular Location||Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGOL2.|
|Tissue Location||Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.
Tanno, Y., et al. Genes Dev. 24(19):2169-2179(2010)
Gnjatic, S., et al. Int. J. Cancer 127(2):381-393(2010)
Sanhaji, M., et al. Mol. Cell. Biol. 30(11):2594-2607(2010)
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Kollu, S., et al. Curr. Biol. 19(24):2108-2113(2009)
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