|Application ||WB, E|
|Other Accession||NP_612138.1, NP_001925.2|
|Calculated MW||26263 Da|
|Antigen Region||72-100 aa|
|Other Names||Homeobox protein DLX-4, Beta protein 1, Homeobox protein DLX-7, Homeobox protein DLX-8, DLX4, BP1, DLX7, DLX8, DLX9|
|Target/Specificity||This DLX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-100 amino acids from the Central region of human DLX4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DLX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BP1, DLX7, DLX8, DLX9|
|Function||May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.|
|Tissue Location||Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.|
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Provided below are standard protocols that you may find useful for product applications.
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Schwartz, A.M., et al. Mod. Pathol. 22(1):1-6(2009)
Man, Y.G., et al. Cancer Biomark 5(1):9-17(2009)
Cavalli, L.R., et al. Cancer Genet. Cytogenet. 187(1):19-24(2008)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
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