|Application ||WB, IHC-P, E|
|Other Accession||Q4KM74, O08547, O08595, NP_004883.2|
|Predicted||Hamster, Mouse, Rat|
|Calculated MW||24593 Da|
|Antigen Region||75-104 aa|
|Other Names||Vesicle-trafficking protein SEC22b, ER-Golgi SNARE of 24 kDa, ERS-24, ERS24, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, SEC22B, SEC22L1|
|Target/Specificity||This SEC22B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the Central region of human SEC22B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC22B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type IV membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Melanosome Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)
Okumura, A.J., et al. J. Biol. Chem. 281(7):4495-4506(2006)
Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)
Nakajima, K., et al. EMBO J. 23(16):3216-3226(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.