|Application ||WB, IHC-P, E|
|Other Accession||Q4KM74, O08547, O08595, NP_004883.2|
|Predicted||Hamster, Mouse, Rat|
|Calculated MW||24593 Da|
|Antigen Region||75-104 aa|
|Other Names||Vesicle-trafficking protein SEC22b, ER-Golgi SNARE of 24 kDa, ERS-24, ERS24, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, SEC22B, SEC22L1|
|Target/Specificity||This SEC22B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-104 amino acids from the Central region of human SEC22B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC22B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type IV membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus, cis-Golgi network membrane. Golgi apparatus, trans-Golgi network membrane. Melanosome Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Chi, A., et al. J. Proteome Res. 5(11):3135-3144(2006)
Okumura, A.J., et al. J. Biol. Chem. 281(7):4495-4506(2006)
Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)
Nakajima, K., et al. EMBO J. 23(16):3216-3226(2004)
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