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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Pak7 Antibody (N-term)   

Mouse Pak7 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Pak7 Antibody (N-term) AP14074a
    Mouse Pak7 Antibody (N-term) (Cat. #AP14074a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Pak7 antibody detected the Pak7 protein (arrow).
  • WB - Mouse Pak7 Antibody (N-term) AP14074a
    Mouse Pak7 Antibody (N-term) (Cat. #AP14074a) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Pak7 antibody detected the Pak7 protein (arrow).
  • IHC-P - Mouse Pak7 Antibody (N-term) AP14074a
    Mouse Pak7 Antibody (N-term) (AP14074a)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Pak7 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8C015
Other Accession D4A280, NP_766446.2
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 80948 Da
Antigen Region 128-157 aa
Additional Information
Gene ID 241656
Other Names Serine/threonine-protein kinase PAK 7, p21-activated kinase 5, PAK-5, p21-activated kinase 7, PAK-7, Pak7, Pak5
Target/Specificity This Mouse Pak7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the N-terminal region of mouse Pak7.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Pak7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pak7
Synonyms Pak5
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity).
Cellular Location Mitochondrion. Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Tissue Location Highly expressed in brain and eye. Also expressed in adrenal gland, pancreas, prostate and testes. Within the brain, expression is restricted to neurons. Present in brain but not in kidney, lung and spleen (at protein level)
Research Areas
Citations (0)

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Background

The activated kinase acts on a variety of targets (By similarity).

References

Gobert, R.P., et al. Mol. Cell. Biol. 29(6):1538-1553(2009)
Nekrasova, T., et al. Dev. Biol. 322(1):95-108(2008)
Pagliarini, D.J., et al. Cell 134(1):112-123(2008)
Sapir, T., et al. J. Neurosci. 28(22):5710-5720(2008)
Trinidad, J.C., et al. Mol. Cell Proteomics 5(5):914-922(2006)

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$ 295.00
$ 99.00
Cat# AP14074a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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