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Mouse Pdk2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Pdk2 Antibody (N-term) AP14075a
    Mouse Pdk2 Antibody (N-term) (Cat. #AP14075a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Pdk2 antibody detected the Pdk2 protein (arrow).
  • WB - Mouse Pdk2 Antibody (N-term) AP14075a
    Western blot analysis of Pdk2 (arrow) using rabbit polyclonal Mouse Pdk2 Antibody (N-term) (Cat. #AP14075a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Pdk2 gene.
  • WB - Mouse Pdk2 Antibody (N-term) AP14075a
    Mouse Pdk2 Antibody (N-term) (Cat. #AP14075a) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Pdk2 antibody detected the Pdk2 protein (arrow).
  • IHC-P - Mouse Pdk2 Antibody (N-term) AP14075a
    Mouse Pdk2 Antibody (N-term) (AP14075a)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Pdk2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9JK42
Other Accession Q64536, Q15119, NP_598428.2
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46041 Da
Antigen Region 78-107 aa
Additional Information
Gene ID 18604
Other Names [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, Pdk2
Target/Specificity This Mouse Pdk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-107 amino acids from the N-terminal region of mouse Pdk2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Pdk2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pdk2
Function Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.
Cellular Location Mitochondrion matrix
Tissue Location Detected in heart (at protein level).
Research Areas
Citations (0)

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Pdk2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.


Sun, W., et al. Clin. Cancer Res. 15(2):476-484(2009)
Pagliarini, D.J., et al. Cell 134(1):112-123(2008)
Osafune, K., et al. Development 133(1):151-161(2006)
Papin, J., et al. Curr. Opin. Biotechnol. 15(1):78-81(2004)
Mootha, V.K., et al. Cell 115(5):629-640(2003)

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$ 295.00
$ 99.00
Cat# AP14075a
(40 western blots)
Availability: In Stock
Bulk Size
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