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TARBP2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TARBP2 Antibody (N-term) AP14108A
    TARBP2 Antibody (N-term) (Cat. #AP14108a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the TARBP2 antibody detected the TARBP2 protein (arrow).
  • IHC-P - TARBP2 Antibody (N-term) AP14108A
    TARBP2 Antibody (N-term) (AP14108a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TARBP2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15633
Other Accession Q6GPZ1, Q3SWU0, P97473, Q0IIG6, NP_599151.2, NP_599150.1
Reactivity Human
Predicted Bovine, Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39039 Da
Antigen Region 60-89 aa
Additional Information
Gene ID 6895
Other Names RISC-loading complex subunit TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}, TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}, TRBP
Target/Specificity This TARBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human TARBP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTARBP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}
Synonyms TRBP
Function Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.
Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Nucleus
Research Areas
Citations (0)

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HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.


Garre, P., et al. Nat. Genet. 42(10):817-818(2010)
Wilker, E.H., et al. Environ. Health Perspect. 118(7):943-948(2010)
Boni, V., et al. Pharmacogenomics J. (2010) In press :
Wang, H.W., et al. Nat. Struct. Mol. Biol. 16(11):1148-1153(2009)
Lau, P.W., et al. Structure 17(10):1326-1332(2009)

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$ 295.00
$ 99.00
Cat# AP14108A
(40 western blots)
Availability: In Stock
Bulk Size
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