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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Ksr1 Antibody (C-term)   

Mouse Ksr1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Ksr1 Antibody (C-term) AP14150B
    Mouse Ksr1 Antibody (C-term) (Cat. #AP14150b) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Ksr1 antibody detected the Ksr1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q61097
Other Accession NP_038599.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 96755 Da
Antigen Region 719-747 aa
Additional Information
Gene ID 16706
Other Names Kinase suppressor of Ras 1, mKSR1, Protein Hb, Ksr1, Ksr
Target/Specificity This Mouse Ksr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 719-747 amino acids from the C-terminal region of mouse Ksr1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Ksr1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ksr1
Synonyms Ksr
Function Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases (PubMed:10409742, PubMed:12932319, PubMed:21102438). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (PubMed:21102438). Does not have kinase activity by itself (Probable).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cell projection, ruffle membrane. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IVT5}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery
Tissue Location Expressed in brain, spleen and testis. Isoform 1 is highly expressed spleen and weakly in testis, and isoform 2 is highly expressed in brain and weakly in testis
Research Areas
Citations (0)

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Background

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

References

Costanzo-Garvey, D.L., et al. Cell Metab. 10(5):366-378(2009)
McKay, M.M., et al. Proc. Natl. Acad. Sci. U.S.A. 106(27):11022-11027(2009)
Razidlo, G.L., et al. J. Biol. Chem. 284(11):6705-6715(2009)
Giurisato, E., et al. Mol. Cell. Biol. 29(6):1554-1564(2009)
Casar, B., et al. Mol. Cell. Biol. 29(5):1338-1353(2009)

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$ 295.00
$ 99.00
Cat# AP14150B
Size:
Quantity:
(40 western blots)
Availability: In Stock
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