|Application ||WB, E|
|Other Accession||NP_976220.2, NP_996825.2, NP_996824.1|
|Calculated MW||94471 Da|
|Antigen Region||795-822 aa|
|Other Names||Leukocyte tyrosine kinase receptor, Ltk|
|Target/Specificity||This Mouse Ltk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 795-822 amino acids from the C-terminal region of mouse Ltk.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Ltk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Isoform B: Endoplasmic reticulum. Note=Retained in the endoplasmic reticulum|
|Tissue Location||Subsets of lymphoid and neuronal cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons.
Li, J., et al. J. Biol. Chem. 283(49):34260-34272(2008)
Yu, X., et al. J. Immunol. 177(10):7042-7049(2006)
Li, N., et al. Hum. Mol. Genet. 13(2):171-179(2004)
Thut, C.J., et al. Dev. Biol. 231(1):63-76(2001)
Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000)
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