|Application ||WB, E|
|Calculated MW||103317 Da|
|Antigen Region||585-613 aa|
|Other Names||SCY1-like protein 2, Coated vesicle-associated kinase of 104 kDa, Scyl2, Cvak104, D10Ertd802e|
|Target/Specificity||This Mouse Scyl2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 585-613 amino acids from the Central region of mouse Scyl2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Scyl2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. May be a serine/threonine-protein kinase. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Note=Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes (By similarity)|
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Provided below are standard protocols that you may find useful for product applications.
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. Scyl2 may be a serine/threonine-protein kinase. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (By similarity).
Duwel, M., et al. Mol. Biol. Cell 17(10):4513-4525(2006)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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