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NUP88 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NUP88 Antibody (C-term) AP14169b
    NUP88 Antibody (C-term) (Cat. #AP14169b) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the NUP88 antibody detected the NUP88 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99567
Other Accession O08658, Q8CEC0, NP_002523.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 701-730 aa
Additional Information
Other Names Nuclear pore complex protein Nup88, 88 kDa nucleoporin, Nucleoporin Nup88, NUP88
Target/Specificity This NUP88 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-730 amino acids from the C-terminal region of human NUP88.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNUP88 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUP88
Function Essential component of nuclear pore complex.
Cellular Location Nucleus, nuclear pore complex.
Tissue Location Ubiquitous. EMBL; Y08612; CAA69904.1; -; mRNA EMBL; CH471108; EAW90340.1; -; Genomic_DNA EMBL; CH471108; EAW90342.1; -; Genomic_DNA EMBL; BC000335; AAH00335.1; -; mRNA CCDS; CCDS11070.1; - RefSeq; NP_001307582.1; NM_001320653.1 RefSeq; NP_002523.2; NM_002532.5 UniGene; Hs.584784; - UniGene; Hs.733301; - ProteinModelPortal; Q99567; - SMR; Q99567; - BioGrid; 110981; 42 IntAct; Q99567; 25 MINT; MINT-191368; - STRING; 9606.ENSP00000458954; - TCDB; 1.I.1.1.3; the nuclear pore complex (npc) family iPTMnet; Q99567; - PhosphoSitePlus; Q99567; - BioMuta; NUP88; - DMDM; 25008854; - EPD; Q99567; - MaxQB; Q99567; - PaxDb; Q99567; - PeptideAtlas; Q99567; - PRIDE; Q99567; - Ensembl; ENST00000573584; ENSP00000458954; ENSG00000108559 GeneID; 4927; - KEGG; hsa:4927; - UCSC; uc002gbo.3; human CTD; 4927; - DisGeNET; 4927; - GeneCards; NUP88; - HGNC; HGNC:8067; NUP88 HPA; CAB002209; - HPA; HPA021816; - MIM; 602552; gene neXtProt; NX_Q99567; - OpenTargets; ENSG00000108559; - PharmGKB; PA31855; - eggNOG; KOG4460; Eukaryota eggNOG; ENOG410YC30; LUCA GeneTree; ENSGT00390000015063; - HOGENOM; HOG000234330; - HOVERGEN; HBG052700; - InParanoid; Q99567; - KO; K14318; - OMA; AWYPSEI; - OrthoDB; EOG091G0O97; - PhylomeDB; Q99567; - TreeFam; TF105307; - BioCyc; ZFISH:ENSG00000108559-MONOMER; - Reactome; R-HSA-1169408; ISG15 antiviral mechanism Reactome; R-HSA-159227; Transport of the SLBP independent Mature mRNA Reactome; R-HSA-159230; Transport of the SLBP Dependant Mature mRNA Reactome; R-HSA-159231; Transport of Mature mRNA Derived from an Intronless Transcript Reactome; R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript Reactome; R-HSA-165054; Rev-mediated nuclear export of HIV RNA Reactome; R-HSA-168271; Transport of Ribonucleoproteins into the Host Nucleus Reactome; R-HSA-168276; NS1 Mediated Effects on Host Pathways Reactome; R-HSA-168325; Viral Messenger RNA Synthesis Reactome; R-HSA-168333; NEP/NS2 Interacts with the Cellular Export Machinery Reactome; R-HSA-170822; Regulation of Glucokinase by Glucokinase Regulatory Protein Reactome; R-HSA-180746; Nuclear import of Rev protein Reactome; R-HSA-180910; Vpr-mediated nuclear import of PICs Reactome; R-HSA-191859; snRNP Assembly Reactome; R-HSA-3108214; SUMOylation of DNA damage response and repair proteins Reactome; R-HSA-3301854; Nuclear Pore Complex (NPC) Disassembly Reactome; R-HSA-3371453; Regulation of HSF1-mediated heat shock response Reactome; R-HSA-4570464; SUMOylation of RNA binding proteins Reactome; R-HSA-4615885; SUMOylation of DNA replication proteins Reactome; R-HSA-5578749; Transcriptional regulation by small RNAs Reactome; R-HSA-6784531; tRNA processing in the nucleus ChiTaRS; NUP88; human GeneWiki; NUP88; - GenomeRNAi; 4927; - PRO; PR:Q99567; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000108559; - CleanEx; HS_NUP88; - ExpressionAtlas; Q99567; baseline and differential Genevisible; Q99567; HS GO; GO:0005829; C:cytosol; TAS:Reactome GO; GO:0005643; C:nuclear pore; IDA:MGI GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0005215; F:transporter activity; TAS:ProtInc GO; GO:0031047; P:gene silencing by RNA; TAS:Reactome GO; GO:0075733; P:intracellular transport of virus; TAS:Reactome GO; GO:0007067; P:mitotic nuclear division; IEA:Ensembl GO; GO:0007077; P:mitotic nuclear envelope disassembly; TAS:Reactome GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central GO; GO:0016925; P:protein sumoylation; TAS:Reactome GO; GO:1900034; P:regulation of cellular response to heat; TAS:Reactome GO; GO:0010827; P:regulation of glucose transport; TAS:Reactome GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central GO; GO:0006409; P:tRNA export from nucleus; TAS:Reactome GO; GO:0016032; P:viral process; TAS:Reactome GO; GO:0019083; P:viral transcription; TAS:Reactome InterPro; IPR019321; Nucleoporin_Nup88 Pfam; PF10168; Nup88; 1 1: Evidence at protein level; Acetylation; Coiled coil; Complete proteome; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transport INIT_MET 1 1 Removed. CHAIN 2 741 Nuclear pore complex protein Nup88 /FTId=PRO_0000204887 COILED 585 651 MOD_RES 2 2 N-acetylalanine MOD_RES 35 35 Phosphoserine MOD_RES 50 50 Phosphoserine MOD_RES 379 379 Phosphoserine MOD_RES 437 437 Phosphoserine MOD_RES 442 442 Phosphoserine MOD_RES 517 517 Phosphoserine MOD_RES 525 525 Phosphothreonine MOD_RES 540 540 Phosphoserine MOD_RES 698 698 Phosphoserine {ECO:0000250|UniProtKB:Q8CEC0} VARIANT 289 289 N -> S (in dbSNP:rs1806245) /FTId=VAR_029340 CONFLICT 247 247 A -> D (in Ref. 1; CAA69904) CONFLICT 291 301 GKLLGPLPMHP -> WKAVGSIAHAS (in Ref. 1; CAA69904). CONFLICT 456 456 K -> R (in Ref. 1; CAA69904) CONFLICT 518 518 P -> S (in Ref. 1; CAA69904) SEQUENCE 741 AA; 83542 MW; 954A8E2E203BC20B CRC64; MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR LLCINPPLFE IYQVLLSPTQ HHVALIGIKG LMVLELPKRW GKNSEFEGGK STVNCSTTPV AERFFTSSTS LTLKHAAWYP SEILDPHVVL LTSDNVIRIY SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA FDFGPLAAVP KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE KSWDSRIDLI PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK CPSRYHCTHE AGVHSVGLTW IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE HILCTKPLPC RQPAPIRGFW IVPDILGPTM ICITSTYECL IWPLLSTVHP ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS VANPAFLKAS EKDIAPPPEE CLQLLSRATQ VFREQYILKQ DLAKEEIQRR VKLLCDQKKK QLEDLSYCRE ERKSLREMAE RLADKYEEAK EKQEDIMNRM KKLLHSFHSE LPVLSDSERD MKKELQLIPD QLRHLGNAIK QVTMKKDYQQ QKMEKVLSLP KPTIILSAYQ RKCIQSILKE EGEHIREMVK QINDIRNHVN F
Research Areas
Citations (0)

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Background

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.

References

Hashizume, C., et al. Mol. Cancer 9, 119 (2010) :
Brustmann, H., et al. Ann Diagn Pathol 13(5):303-307(2009)
Cheng, Y.T., et al. Plant Cell 21(8):2503-2516(2009)
Andres-Hernando, A., et al. J. Biol. Chem. 283(36):25082-25090(2008)
Kodiha, M., et al. Biochim. Biophys. Acta 1783(3):405-418(2008)

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$ 295.00
$ 99.00
Cat# AP14169b
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(40 western blots)
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