|Application ||FC, WB, IHC-P, E|
|Other Accession||Q06000, P49923, P11152, P11151, NP_000228.1, Q29524|
|Predicted||Bovine, Mouse, Pig, Rat|
|Calculated MW||53162 Da|
|Antigen Region||300-327 aa|
|Other Names||Lipoprotein lipase, LPL, LPL, LIPD|
|Target/Specificity||This LPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human LPL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LPL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq].
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)
Zabaneh, D., et al. PLoS ONE 5 (8) (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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