|Application ||WB, E|
|Calculated MW||74141 Da|
|Antigen Region||147-178 aa|
|Other Names||Histidine decarboxylase, HDC, HDC|
|Target/Specificity||This HDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-178 amino acids from the N-terminal region of human HDC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HDC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the biosynthesis of histamine from histidine.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.
Gervasini, G., et al. Allergy (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ercan-Sencicek, A.G., et al. N. Engl. J. Med. 362(20):1901-1908(2010)
Jeong, H.J., et al. Cell. Mol. Life Sci. 66(7):1309-1319(2009)
Siezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009)
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