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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Camk2b Antibody (Center)   

Mouse Camk2b Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Camk2b Antibody (Center) AP14185c
    Mouse Camk2b Antibody (Center) (Cat. #AP14185c) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Camk2b antibody detected the Camk2b protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28652
Other Accession P08413, Q13554, Q3MHJ9, NP_031621.3
Reactivity Mouse
Predicted Bovine, Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60461 Da
Antigen Region 168-196 aa
Additional Information
Gene ID 12323
Other Names Calcium/calmodulin-dependent protein kinase type II subunit beta, CaM kinase II subunit beta, CaMK-II subunit beta, Camk2b, Camk2d
Target/Specificity This Mouse Camk2b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the Central region of mouse Camk2b.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Camk2b Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Camk2b
Synonyms Camk2d
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)

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CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).


Martinez-Pena y Valenzuela, I., et al. J. Neurosci. 30(37):12455-12465(2010)
Jin, X.L., et al. Biol. Reprod. 82(2):459-468(2010)
van Woerden, G.M., et al. Nat. Neurosci. 12(7):823-825(2009)
Butcher, A.J., et al. J. Biol. Chem. 284(25):17147-17156(2009)
Cheng, T.W., et al. Eur. J. Neurosci. 29(6):1083-1095(2009)

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$ 295.00
$ 99.00
Cat# AP14185c
(40 western blots)
Availability: In Stock
Bulk Size
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