|Application ||WB, IHC-P, E|
|Calculated MW||33207 Da|
|Antigen Region||63-91 aa|
|Other Names||Junctional adhesion molecule B, JAM-B, Junctional adhesion molecule 2, JAM-2, Vascular endothelial junction-associated molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM|
|Target/Specificity||This JAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the N-terminal region of human JAM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JAM2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the processes of lymphocyte homing to secondary lymphoid organs.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.|
|Tissue Location||Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs. [provided by RefSeq].
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Ueki, T., et al. Microvasc. Res. 75(2):269-278(2008)
Weber, C., et al. Nat. Rev. Immunol. 7(6):467-477(2007)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
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