|Application ||WB, IHC-P, E|
|Other Accession||NP_001075424.1, NP_003826.2|
|Calculated MW||76966 Da|
|Antigen Region||149-178 aa|
|Other Names||Regulator of G-protein signaling 9, RGS9, RGS9|
|Target/Specificity||This RGS9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the N-terminal region of human RGS9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGS9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).|
|Cellular Location||Isoform 3: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP.|
|Tissue Location||Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Celver, J., et al. J. Neurochem. 114(3):739-749(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Greenbaum, L., et al. Psychiatr. Genet. 20(1):47-48(2010)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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