|Application ||WB, E|
|Calculated MW||42195 Da|
|Antigen Region||1-30 aa|
|Other Names||Neuropeptide Y receptor type 4, NPY4-R, Pancreatic polypeptide receptor 1, PP1, NPY4R, PPYR1|
|Target/Specificity||This PPYR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PPYR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPYR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Umeda, T., et al. Peptides 30(8):1441-1447(2009)
Sha, B.Y., et al. J. Hum. Genet. 54(4):199-202(2009)
Gao, Y., et al. Biochemistry 47(43):11367-11376(2008)
Parker, E., et al. Eur. J. Pharmacol. 440 (2-3), 173-187 (2002) :
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