|Application ||WB, E|
|Other Accession||NP_001011666.1, NP_004895.2, NP_878901.2|
|Calculated MW||56918 Da|
|Antigen Region||1-30 aa|
|Other Names||Cyclic AMP-responsive element-binding protein 5, CREB-5, cAMP-responsive element-binding protein 5, CRE-BPa, CREB5, CREBPA|
|Target/Specificity||This CREB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CREB5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CREB5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the cAMP response element and activates transcription.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Xu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2136-2140(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Lesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008)
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
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