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TAU (MAPT) Antibody (S720)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • IHC - TAU (MAPT) Antibody (S720) AP1425c
    AP1425c staining TAU in Monkey brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
  • WB - TAU (MAPT) Antibody (S720) AP1425c
    MAPT Antibody (pS720) (Cat.# AP1425c) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the MAPT antibody detected the MAPT protein (arrow).
  • IHC-P - TAU (MAPT) Antibody (S720) AP1425c
    Formalin-fixed and paraffin-embedded human brain tissue reacted with MAPT Antibody (S720) (Cat.#AP1425c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10636
Other Accession P19332, P10637, P29172
Reactivity Human, Cynomolgus Monkey
Predicted Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 78928 Da
Antigen Region 699-728 aa
Additional Information
Gene ID 4137
Other Names Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU
Target/Specificity This TAU(MAPT) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 699-728 amino acids from human TAU(MAPT).
Dilution IHC~~1:25
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTAU (MAPT) Antibody (S720) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAPTL, MTBT1, TAU
Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Cellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components
Tissue Location Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system
Research Areas
Citations (0)

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MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.


McCulloch,C.C., Hum. Genet. 123 (3), 257-265 (2008)
Mateo,I., Dement Geriatr Cogn Disord 25 (4), 317-320 (2008)
Beck,J., Brain 131 (PT 3), 706-720 (2008)

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$ 295.00
$ 99.00
Cat# AP1425c
(40 western blots)
Availability: In Stock
Bulk Size
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