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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Irak3 Antibody (C-term)   

Mouse Irak3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Irak3 Antibody (C-term) AP14260B
    Mouse Irak3 Antibody (C-term) (Cat. #AP14260b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Irak3 antibody detected the Irak3 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8K4B2
Other Accession NP_082955.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68455 Da
Antigen Region 517-544 aa
Additional Information
Gene ID 73914
Other Names Interleukin-1 receptor-associated kinase 3, IRAK-3, IL-1 receptor-associated kinase M, IRAK-M, Irak3 {ECO:0000312|MGI:MGI:1921164}
Target/Specificity This Mouse Irak3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 517-544 amino acids from the C-terminal region of mouse Irak3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Irak3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Irak3 {ECO:0000312|MGI:MGI:1921164}
Function Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Tissue Location Highly expressed in liver and thymus and at lower levels in heart, brain, spleen and kidney
Research Areas
Citations (0)

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Background

Irak3 inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

References

Turnis, M.E., et al. J. Immunol. 185(7):4223-4232(2010)
Hubbard, L.L., et al. J. Immunol. 184(11):6299-6308(2010)
Seki, M., et al. J. Immunol. 184(3):1410-1418(2010)
Lyn-Kew, K., et al. PLoS ONE 5 (6), E11145 (2010) :
Su, J., et al. J Innate Immun 1(2):164-174(2009)

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Cat# AP14260B
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(40 western blots)
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