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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   Mouse Matk Antibody (C-term)   

Mouse Matk Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Matk Antibody (C-term) AP14271b
    Mouse Matk Antibody (C-term) (Cat. #AP14271b) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Matk antibody detected the Matk protein (arrow).
  • IHC-P - Mouse Matk Antibody (C-term) AP14271b
    Mouse Matk Antibody (C-term) (AP14271b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Matk Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P41242
Other Accession P41243, NP_034898.1
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 56056 Da
Antigen Region 477-505 aa
Additional Information
Gene ID 17179
Other Names Megakaryocyte-associated tyrosine-protein kinase, Protein kinase NTK, Tyrosine-protein kinase CTK, Matk, Ctk, Ntk
Target/Specificity This Mouse Matk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-505 amino acids from the C-terminal region of mouse Matk.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Matk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Matk
Synonyms Ctk, Ntk
Function Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Cellular Location Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
Tissue Location Most abundant in brain, and to a lesser extent in the spleen, the thymus and the liver. Also found in the T-cell lineage
Research Areas
Citations (0)

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Background

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

References

Lee, B.C., et al. Blood 108(3):904-907(2006)
Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000)
Puttagunta, R., et al. Genome Res. 10(9):1369-1380(2000)
Samokhvalov, I., et al. Biochem. Mol. Biol. Int. 43(1):115-122(1997)
Kozak, C.A., et al. Mamm. Genome 7(2):164-165(1996)

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$ 295.00
$ 99.00
Cat# AP14271b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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