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Mouse Matk Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P41242 |
| Other Accession | P41243, NP_034898.1 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56056 Da |
| Antigen Region | 477-505 aa |
| Gene ID | 17179 |
|---|---|
| Other Names | Megakaryocyte-associated tyrosine-protein kinase, Protein kinase NTK, Tyrosine-protein kinase CTK, Matk, Ctk, Ntk |
| Target/Specificity | This Mouse Matk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-505 amino acids from the C-terminal region of mouse Matk. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Matk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Matk |
|---|---|
| Synonyms | Ctk, Ntk |
| Function | Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC- family members in brain by specifically phosphorylating their C- terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T- cell proliferation. |
| Cellular Location | Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation. |
| Tissue Location | Most abundant in brain, and to a lesser extent in the spleen, the thymus and the liver. Also found in the T-cell lineage |
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Provided below are standard protocols that you may find useful for product applications.
Background
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
References
Lee, B.C., et al. Blood 108(3):904-907(2006)
Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000)
Puttagunta, R., et al. Genome Res. 10(9):1369-1380(2000)
Samokhvalov, I., et al. Biochem. Mol. Biol. Int. 43(1):115-122(1997)
Kozak, C.A., et al. Mamm. Genome 7(2):164-165(1996)
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