|Application ||WB, IHC-P, E|
|Other Accession||P41243, NP_034898.1|
|Calculated MW||56056 Da|
|Antigen Region||477-505 aa|
|Other Names||Megakaryocyte-associated tyrosine-protein kinase, Protein kinase NTK, Tyrosine-protein kinase CTK, Matk, Ctk, Ntk|
|Target/Specificity||This Mouse Matk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-505 amino acids from the C-terminal region of mouse Matk.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Matk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.|
|Cellular Location||Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.|
|Tissue Location||Most abundant in brain, and to a lesser extent in the spleen, the thymus and the liver. Also found in the T-cell lineage|
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Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Lee, B.C., et al. Blood 108(3):904-907(2006)
Robinson, D.R., et al. Oncogene 19(49):5548-5557(2000)
Puttagunta, R., et al. Genome Res. 10(9):1369-1380(2000)
Samokhvalov, I., et al. Biochem. Mol. Biol. Int. 43(1):115-122(1997)
Kozak, C.A., et al. Mamm. Genome 7(2):164-165(1996)
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