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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Mastl Antibody (Center)   

Mouse Mastl Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Mastl Antibody (Center) AP14289c
    Mouse Mastl Antibody (Center) (Cat. #AP14289c) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Mastl antibody detected the Mastl protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8C0P0
Other Accession NP_080255.3
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 95975 Da
Antigen Region 561-589 aa
Additional Information
Gene ID 67121
Other Names Serine/threonine-protein kinase greatwall, GW, GWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L, Mastl, Gw, Gwl
Target/Specificity This Mouse Mastl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-589 amino acids from the Central region of mouse Mastl.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Mastl Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mastl
Synonyms Gw, Gwl
Function Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes
Research Areas
Citations (0)

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Serine/threonine kinase. Mediates mitotic entry and maintenance. Maintains the correct equilibrium between cyclin B1-CDK1 and protein phosphatase 2A (PP2A) by promoting the inactivation of PP2A. Phosphorylates histone protein in vitro. May be involved in megakaryocyte differentiation (By similarity).


Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
Piao, Y., et al. Genome Res. 11(9):1553-1558(2001)

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$ 295.00
$ 99.00
Cat# AP14289c
(40 western blots)
Availability: In Stock
Bulk Size
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