|Application ||WB, IHC-P, E|
|Other Accession||Q9R0K8, O88452, NP_003705.1|
|Calculated MW||33249 Da|
|Antigen Region||273-302 aa|
|Other Names||Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2|
|Target/Specificity||This STC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the C-terminal region of human STC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has an anti-hypocalcemic action on calcium and phosphate homeostasis.|
|Tissue Location||Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Law, A.Y., et al. Exp. Cell Res. 316(3):466-476(2010)
Volland, S., et al. Int. J. Cancer 125(9):2049-2057(2009)
Ieta, K., et al. Int. J. Cancer 125(4):926-931(2009)
Tamura, K., et al. Cancer Sci. 100(5):914-919(2009)
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