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RRP1B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14684 |
| Other Accession | NP_055871.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 84428 Da |
| Antigen Region | 571-598 aa |
| Gene ID | 23076 |
|---|---|
| Other Names | Ribosomal RNA processing protein 1 homolog B, RRP1-like protein B, RRP1B, KIAA0179 |
| Target/Specificity | This RRP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-598 amino acids from the N-terminal region of human RRP1B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RRP1B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RRP1B |
|---|---|
| Synonyms | KIAA0179 |
| Function | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RRP1B belongs to the RRP1 family. It may be a novel susceptibility gene for breast cancer progression and metastasis.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Paik, J.C., et al. J. Biol. Chem. 285(9):6348-6363(2010)
Crawford, N.P., et al. J. Biol. Chem. 284(42):28660-28673(2009)
Hsieh, S.M., et al. Breast Cancer Res. 11 (5), R75 (2009) :
Crawford, N.P., et al. PLoS Genet. 3 (11), E214 (2007) :
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