|Application ||WB, E|
|Other Accession||NP_937862.1, NP_937861.1, NP_005528.3|
|Calculated MW||46738 Da|
|Antigen Region||1-30 aa|
|Other Names||Inhibitor of growth protein 1, ING1|
|Target/Specificity||This ING1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ING1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ING1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.|
|Tissue Location||Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Zhu, Z., et al. Hepatology 49(2):504-512(2009)
Sayan, B., et al. Hybridoma (Larchmt) (2009) In press :
Tallen, G., et al. Oncol. Res. 18 (2-3), 95-105 (2009) :
Halaschek-Wiener, J., et al. PLoS ONE 4 (8), E6641 (2009) :
Han, X., et al. Nat. Cell Biol. 10(11):1333-1340(2008)
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