|Application ||WB, E|
|Other Accession||Q9DBR1, Q9VM71, Q5ZIP4, NP_036387.2|
|Predicted||Chicken, Drosophila, Mouse|
|Calculated MW||108582 Da|
|Antigen Region||48-76 aa|
|Other Names||5'-3' exoribonuclease 2, 3113-, DHM1-like protein, DHP protein, XRN2|
|Target/Specificity||This XRN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-76 amino acids from the N-terminal region of human XRN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||XRN2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).|
|Cellular Location||Nucleus, nucleolus|
|Tissue Location||Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known.
Lu, Y., et al. Oncogene 29(7):1041-1049(2010)
Yang, X.C., et al. Mol. Cell. Biol. 29(1):31-42(2009)
Kaneko, S., et al. Genes Dev. 21(14):1779-1789(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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