|Application ||WB, E|
|Other Accession||Q61074, Q4R4V2, P79126, NP_817092.1|
|Predicted||Bovine, Monkey, Mouse|
|Calculated MW||59272 Da|
|Antigen Region||64-92 aa|
|Other Names||Protein phosphatase 1G, Protein phosphatase 1C, Protein phosphatase 2C isoform gamma, PP2C-gamma, Protein phosphatase magnesium-dependent 1 gamma, PPM1G, PPM1C|
|Target/Specificity||This PPM1G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the N-terminal region of human PPM1G.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPM1G Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Widely expressed. Most abundant in testis, skeletal muscle, and heart|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Suh, E.J., et al. Biochem. Biophys. Res. Commun. 386(3):467-470(2009)
Petri, S., et al. J. Cell Biol. 179(3):451-465(2007)
Allemand, E., et al. Nat. Struct. Mol. Biol. 14(7):630-638(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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