|Application ||WB, E|
|Other Accession||NP_001041695.1, NP_000665.1|
|Calculated MW||36512 Da|
|Antigen Region||298-326 aa|
|Other Names||Adenosine receptor A1, ADORA1|
|Target/Specificity||This ADORA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-326 amino acids from the C-terminal region of human ADORA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADORA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene.
Lane, J.R., et al. Biochem. Pharmacol. 80(8):1180-1189(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wagner, A.K., et al. Epilepsy Res. 90(3):259-272(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
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