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DSG1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q02413 |
| Other Accession | NP_001933.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 113748 Da |
| Antigen Region | 471-499 aa |
| Gene ID | 1828 |
|---|---|
| Other Names | Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen, DSG1, CDHF4 |
| Target/Specificity | This DSG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-499 amino acids from the Central region of human DSG1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DSG1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DSG1 |
|---|---|
| Synonyms | CDHF4 |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q7TSF1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q7TSF1} Cell junction, desmosome. Cytoplasm. Nucleus |
| Tissue Location | Epidermis, tongue, tonsil and esophagus. |
Provided below are standard protocols that you may find useful for product applications.
Background
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
References
Rothenberg, M.E., et al. Nat. Genet. 42(4):289-291(2010)
Naoe, Y., et al. J. Dermatol. Sci. 57(3):192-198(2010)
Qian, Y., et al. J. Invest. Dermatol. 129(12):2823-2834(2009)
Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009)
Getsios, S., et al. J. Cell Biol. 185(7):1243-1258(2009)
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