|Application ||WB, IHC-P, E|
|Other Accession||NP_003877.2, NP_647450.1|
|Calculated MW||94477 Da|
|Antigen Region||10-36 aa|
|Other Names||A-kinase anchor protein 4, AKAP-4, A-kinase anchor protein 82 kDa, AKAP 82, hAKAP82, Major sperm fibrous sheath protein, HI, Protein kinase A-anchoring protein 4, PRKA4, AKAP4 (HGNC:374), AKAP82|
|Target/Specificity||This AKAP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-36 amino acids from the N-terminal region of human AKAP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AKAP4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major structural component of sperm fibrous sheath. Plays a role in sperm motility.|
|Cellular Location||Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum|
|Tissue Location||Testis specific; only expressed in round spermatids.|
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Provided below are standard protocols that you may find useful for product applications.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Moretti, E., et al. Asian J. Androl. 9(5):641-649(2007)
Lefievre, L., et al. Proteomics 7(17):3066-3084(2007)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Brown, P.R., et al. Biol. Reprod. 68(6):2241-2248(2003)
Ficarro, S., et al. J. Biol. Chem. 278(13):11579-11589(2003)
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