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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Taok2 Antibody (Center)   

Mouse Taok2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Taok2 Antibody (Center) AP14470c
    Mouse Taok2 Antibody (Center) (Cat. #AP14470c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the Taok2 antibody detected the Taok2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZQ29
Other Accession Q9JLS3, NP_001157246.1
Reactivity Human
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 139297 Da
Antigen Region 415-443 aa
Additional Information
Gene ID 381921
Other Names Serine/threonine-protein kinase TAO2, Thousand and one amino acid protein 2, Taok2, Kiaa0881
Target/Specificity This Mouse Taok2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415-443 amino acids from the Central region of mouse Taok2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Taok2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Taok2
Synonyms Kiaa0881
Function Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7- mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity).
Cellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Note=Found to be perinuclear and localized to vesicular compartment.
Research Areas
Citations (0)

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Taok2 may play a role in apoptotic morphological changes. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases. Prevents MAP3K7-mediated activation of IKKA, and thus NF-kappa-B activation. Phosphorylates itself, MBP, activated MAPK8 and tubulins (By similarity).


Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) :
Thuret, S., et al. Mol. Cell. Neurosci. 25(3):394-405(2004)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Okazaki, N., et al. DNA Res. 10(4):167-180(2003)

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$ 295.00
$ 99.00
Cat# AP14470c
(40 western blots)
Availability: In Stock
Bulk Size
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