|Application ||WB, IHC-P, E|
|Calculated MW||97092 Da|
|Antigen Region||698-727 aa|
|Other Names||Glycogen phosphorylase, muscle form, Myophosphorylase, PYGM|
|Target/Specificity||This PYGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 698-727 amino acids from the C-terminal region of human PYGM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PYGM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.|
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Provided below are standard protocols that you may find useful for product applications.
PYGM catalyzes and regulates the breakdown of glycogen to glucose-1-phosphate. Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5), also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.
Tsoi, S.C., et al., J. Soc. Gynecol. Investig. 10(8):496-502 (2003).
Bruno, C., et al., Neuromuscul. Disord. 12(5):498-500 (2002).
Hadjigeorgiou, G.M., et al., Neuromuscul. Disord. 12(9):824-827 (2002).
Deschauer, M., et al., Mol. Genet. Metab. 74(4):489-491 (2001).
Kubisch, C., et al., Hum. Mutat. 12(1):27-32 (1998).
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