- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||111076 Da|
|Antigen Region||724-752 aa|
|Other Names||SEC23-interacting protein, p125, SEC23IP|
|Target/Specificity||This SEC23IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 724-752 amino acids from the C-terminal region of human SEC23IP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC23IP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).|
|Cellular Location||Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side Endoplasmic reticulum|
|Tissue Location||Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle|
Provided below are standard protocols that you may find useful for product applications.
COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway. [provided by RefSeq].
Ong, Y.S., et al. J. Cell Biol. 190(3):331-345(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Li, H., et al. J. Biol. Chem. 281(21):14748-14755(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Shimoi, W., et al. J. Biol. Chem. 280(11):10141-10148(2005)
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