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SEC23IP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y6Y8 |
| Other Accession | NP_009121.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 111076 Da |
| Antigen Region | 724-752 aa |
| Gene ID | 11196 |
|---|---|
| Other Names | SEC23-interacting protein, p125, SEC23IP |
| Target/Specificity | This SEC23IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 724-752 amino acids from the C-terminal region of human SEC23IP. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEC23IP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEC23IP |
|---|---|
| Function | Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P). |
| Cellular Location | Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum |
| Tissue Location | Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle |
Provided below are standard protocols that you may find useful for product applications.
Background
COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway. [provided by RefSeq].
References
Ong, Y.S., et al. J. Cell Biol. 190(3):331-345(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Li, H., et al. J. Biol. Chem. 281(21):14748-14755(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Shimoi, W., et al. J. Biol. Chem. 280(11):10141-10148(2005)
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