- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||111076 Da|
|Antigen Region||724-752 aa|
|Other Names||SEC23-interacting protein, p125, SEC23IP|
|Target/Specificity||This SEC23IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 724-752 amino acids from the C-terminal region of human SEC23IP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC23IP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).|
|Cellular Location||Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side Endoplasmic reticulum|
|Tissue Location||Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle|
Provided below are standard protocols that you may find useful for product applications.
COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway. [provided by RefSeq].
Ong, Y.S., et al. J. Cell Biol. 190(3):331-345(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Li, H., et al. J. Biol. Chem. 281(21):14748-14755(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Shimoi, W., et al. J. Biol. Chem. 280(11):10141-10148(2005)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.