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SEC23IP Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP14511b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP14511b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
SEC23IP Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q9Y6Y8 |
| Other Accession | NP_009121.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 111076 Da |
SEC23IP Antibody (C-term) - Additional info | |
| Gene ID 11196 | |
| Other Names SEC23IP; SEC23-interacting protein; p125 | |
| Target/Specificity This SEC23IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-752 amino acids from the C-terminal region of human SEC23IP. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SEC23IP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SEC23IP Antibody (C-term) - Protein Information | |
| Name SEC23IP | |
| Function Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P) | |
| Cellular Location Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side Endoplasmic reticulum (Probable) | |
| Tissue Location Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle | |
SEC23IP Antibody (C-term) - Related products
SEC23IP Antibody (C-term) - Application data
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SEC23IP Antibody (C-term) (Cat. #AP14511b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SEC23IP antibody detected the SEC23IP protein (arrow).
SEC23IP Antibody (C-term) - Research Areas
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BACKGROUND
COPII-coated vesicles are involved in protein transport from the endoplasmic reticulum to the Golgi apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway. [provided by RefSeq].
REFERENCES
Ong, Y.S., et al. J. Cell Biol. 190(3):331-345(2010) Trynka, G., et al. Gut 58(8):1078-1083(2009) Li, H., et al. J. Biol. Chem. 281(21):14748-14755(2006) Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006) Shimoi, W., et al. J. Biol. Chem. 280(11):10141-10148(2005)
