|Application ||WB, E|
|Calculated MW||144569 Da|
|Antigen Region||46-74 aa|
|Other Names||Serine/threonine-protein kinase LMTK1, Apoptosis-associated tyrosine kinase, AATYK, Brain apoptosis-associated tyrosine kinase, CDK5-binding protein, Lemur tyrosine kinase 1, p35-binding protein, p35BP, AATK, AATYK, KIAA0641, LMR1, LMTK1|
|Target/Specificity||This AATK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human AATK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AATK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||AATYK, KIAA0641, LMR1, LMTK1|
|Function||May be involved in neuronal differentiation.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear|
|Tissue Location||Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line.
Tomomura, M., et al. Neuroscience 148(2):510-521(2007)
Lee, S., et al. Oncol. Rep. 16(4):747-754(2006)
Honma, N., et al. Biochem. Biophys. Res. Commun. 310(2):398-404(2003)
Tomomura, M., et al. Brain Res. Mol. Brain Res. 112 (1-2), 103-112 (2003) :
Tomomura, M., et al. Oncogene 20(9):1022-1032(2001)
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