|Application ||WB, E|
|Other Accession||Q5U5C5, Q8CCF0, Q7SXM7, NP_056444.3|
|Predicted||Zebrafish, Mouse, Xenopus|
|Calculated MW||55456 Da|
|Antigen Region||334-361 aa|
|Other Names||U4/U6 small nuclear ribonucleoprotein Prp31, Pre-mRNA-processing factor 31, Serologically defined breast cancer antigen NY-BR-99, U4/U6 snRNP 61 kDa protein, Protein 61K, hPrp31, PRPF31, PRP31|
|Target/Specificity||This PRPF31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-361 amino acids from the C-terminal region of human PRPF31.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRPF31 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.|
|Cellular Location||Nucleus speckle. Nucleus, Cajal body. Note=Predominantly found in speckles and in Cajal bodies|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.
Schneider, M., et al. Nat. Struct. Mol. Biol. 17(2):216-221(2010)
Bujakowska, K., et al. Invest. Ophthalmol. Vis. Sci. 50(12):5927-5933(2009)
Potkin, S.G., et al. PLoS ONE 4 (8), E6501 (2009) :
Liu, S., et al. Science 316(5821):115-120(2007)
Sullivan, L.S., et al. Invest. Ophthalmol. Vis. Sci. 47(10):4579-4588(2006)
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