|Application ||WB, E|
|Other Accession||NP_002767.2, NP_665895.1, NP_001070968.1|
|Calculated MW||30170 Da|
|Antigen Region||22-51 aa|
|Other Names||Kallikrein-10, 3421-, Normal epithelial cell-specific 1, Protease serine-like 1, KLK10, NES1, PRSSL1|
|Target/Specificity||This KLK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the N-terminal region of human KLK10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLK10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a tumor-suppressor role for NES1 in breast and prostate cancer.|
|Tissue Location||Expressed in breast, ovary and prostate.|
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Provided below are standard protocols that you may find useful for product applications.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq].
Batra, J., et al. Int. J. Gynecol. Cancer 20(4):529-536(2010)
Klein, R.J., et al. Cancer Prev Res (Phila) 3(5):611-619(2010)
Papageorgis, P., et al. Cancer Res. 70(3):968-978(2010)
Lu, C.Y., et al. Genes Chromosomes Cancer 48(12):1057-1068(2009)
Sardana, G., et al. Clin. Biochem. 42 (13-14), 1483-1486 (2009) :
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