- CITATIONS: 2
|Application ||WB, IHC-P, E|
|Other Accession||P35559, Q9JHR7, Q24K02|
|Calculated MW||117968 Da|
|Antigen Region||406-435 aa|
|Other Names||Insulin-degrading enzyme, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin, IDE|
|Target/Specificity||This IDE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-435 amino acids from the Central region of human IDE.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IDE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.|
|Cellular Location||Cytoplasm. Cell membrane. Secreted. Note=Present at the cell surface of neuron cells The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform|
Provided below are standard protocols that you may find useful for product applications.
IDE belongs to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response.
Vepsalainen,S.,J. Med. Genet. 44 (9), 606-608 (2007)
Kim,M.,J. Biol. Chem. 282 (11), 7825-7832 (2007)
Radulescu,R.T.,Int. J. Oncol. 30 (1), 73-80 (2007)
Li,Q.,Cell 127 (2), 305-316 (2006)
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