|Application ||WB, E|
|Other Accession||NP_003235.1, NP_775299.1|
|Calculated MW||43013 Da|
|Antigen Region||81-109 aa|
|Other Names||Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF|
|Target/Specificity||This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human TGIF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TGIF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
Bengoechea-Alonso, M.T., et al. Oncogene 29(38):5322-5328(2010)
Paulussen, A.D., et al. Eur. J. Hum. Genet. 18(9):999-1005(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Demange, C., et al. Mol. Cell 36(6):1073-1085(2009)
Hamid, R., et al. Mol Oncol 3 (5-6), 451-463 (2009) :
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