|Application ||WB, E|
|Other Accession||NP_005113.1, NP_001070948.1|
|Calculated MW||39942 Da|
|Antigen Region||155-183 aa|
|Other Names||Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR|
|Target/Specificity||This NR1I3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human NR1I3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NR1I3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7.|
|Tissue Location||Predominantly expressed in liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Benet, M., et al. J. Biol. Chem. 285(37):28457-28471(2010)
Oliver, P., et al. Clin. Chem. Lab. Med. 48(5):635-639(2010)
Masuyama, H., et al. Mol. Endocrinol. 24(4):745-753(2010)
Mutoh, S., et al. J. Biol. Chem. 284(50):34785-34792(2009)
Urano, T., et al. Geriatr Gerontol Int 9(3):235-241(2009)
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