|Application ||WB, E|
|Other Accession||Q63801, Q62311, NP_005632.1, NP_647476.1|
|Calculated MW||72668 Da|
|Antigen Region||24-53 aa|
|Other Names||Transcription initiation factor TFIID subunit 6, RNA polymerase II TBP-associated factor subunit E, Transcription initiation factor TFIID 70 kDa subunit, TAF(II)70, TAFII-70, TAFII70, Transcription initiation factor TFIID 80 kDa subunit, TAF(II)80, TAFII-80, TAFII80, TAF6, TAF2E, TAFII70|
|Target/Specificity||This TAF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human TAF6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAF6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.|
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Provided below are standard protocols that you may find useful for product applications.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants.
Theisen, J.W., et al. Mol. Cell. Biol. (2010) In press :
Wilhelm, E., et al. BMC Mol. Biol. 11, 10 (2010) :
Wilhelm, E., et al. PLoS ONE 3 (7), E2721 (2008) :
Frontini, M., et al. Mol. Cell. Biol. 25(11):4638-4649(2005)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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