|Application ||WB, IHC-P, E|
|Other Accession||Q5FWY5, Q7YRC1, NP_003968.2|
|Calculated MW||37636 Da|
|Antigen Region||293-321 aa|
|Other Names||AH receptor-interacting protein, AIP, Aryl-hydrocarbon receptor-interacting protein, HBV X-associated protein 2, XAP-2, Immunophilin homolog ARA9, AIP, XAP2|
|Target/Specificity||This AIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human AIP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AIP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.|
|Tissue Location||Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus.
Daly, A.F., et al. J. Clin. Endocrinol. Metab. 95 (11), E373-E383 (2010) :
Stratakis, C.A., et al. Clin. Genet. 78(5):457-463(2010)
Occhi, G., et al. Eur. J. Endocrinol. 163(3):369-376(2010)
Igreja, S., et al. Hum. Mutat. 31(8):950-960(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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