Mouse Clk1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P22518 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 57093 Da |
Antigen Region | 53-80 aa |
Gene ID | 12747 |
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Other Names | Dual specificity protein kinase CLK1, CDC-like kinase 1, Protein kinase STY, Clk1, Clk, Sty |
Target/Specificity | This Mouse Clk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-80 amino acids from the N-terminal region of mouse Clk1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Clk1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Clk1 {ECO:0000312|MGI:MGI:107403} |
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Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates (PubMed:1825055, PubMed:1986248, PubMed:9307018). Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:8617202, PubMed:9307018). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity). |
Cellular Location | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
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