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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Sgk223 Antibody (N-term)   

Mouse Sgk223 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Sgk223 Antibody (N-term) AP14635a
    Mouse Sgk223 Antibody (N-term) (Cat. #AP14635a) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Sgk223 antibody detected the Sgk223 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q571I4
Other Accession NP_766499.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 147945 Da
Antigen Region 195-224 aa
Additional Information
Gene ID 244418
Other Names Tyrosine-protein kinase SgK223, Sugen kinase 223, Sgk223, D8Ertd82e
Target/Specificity This Mouse Sgk223 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the N-terminal region of mouse Sgk223.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Sgk223 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Prag1 {ECO:0000312|MGI:MGI:1196223}
Function Catalytically inactive protein kinase that acts as a scaffold protein (By similarity). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (PubMed:25038227).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:D3ZMK9}. Nucleus. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q86YV5}. Note=Colocalized with NOTCH1 in the nucleus (PubMed:25038227)
Research Areas
Citations (0)

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PRAGMIN is also known as SGK223 (sugen kinase 223). The rat homolog was originally identified in a yeast two-hybrid screen for Rnd2 effector proteins expressed in neural cells. Rat Pragmin was found to stimulate RhoA activity for the regulation of neurite outgrowth.


Tanaka, H., et al. J. Biol. Chem. 281(15):10355-10364(2006)

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$ 295.00
$ 99.00
Cat# AP14635a
(40 western blots)
Availability: In Stock
Bulk Size
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