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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PDE8A Antibody (Center) (L572)   

PDE8A Antibody (Center) (L572)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDE8A Antibody (Center) (L572) AP1463c
    Western blot analysis of PDE8A Antibody (Center) (L572) (Cat# AP1463c) in HL60 cell line lysates (35ug/lane). PDE8A (arrow) was detected using the purified Pab.
  • IHC-P - PDE8A Antibody (Center) (L572) AP1463c
    Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PDE8A antibody (Center) (L572)(Cat.#AP1463c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60658
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 93304 Da
Antigen Region 557-587 aa
Additional Information
Gene ID 5151
Other Names High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A, PDE8A
Target/Specificity This PDE8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-587 amino acids from the Central region of human PDE8A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDE8A Antibody (Center) (L572) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE8A
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Tissue Location Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon
Research Areas
Citations (0)

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PDE8A plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase, which has a high affinity for cAMP, may be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.


Wu,P., Proc. Natl. Acad. Sci. U.S.A. 101 (51), 17634-17639 (2004)
Gamanuma,M., Cell. Signal. 15 (6), 565-574 (2003)

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$ 295.00
$ 99.00
Cat# AP1463c
(40 western blots)
Availability: In Stock
Bulk Size
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