|Application ||WB, IHC-P, E|
|Calculated MW||93304 Da|
|Antigen Region||557-587 aa|
|Other Names||High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A, PDE8A|
|Target/Specificity||This PDE8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-587 amino acids from the Central region of human PDE8A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE8A Antibody (Center) (L572) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.|
|Tissue Location||Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon|
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Provided below are standard protocols that you may find useful for product applications.
PDE8A plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase, which has a high affinity for cAMP, may be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Wu,P., Proc. Natl. Acad. Sci. U.S.A. 101 (51), 17634-17639 (2004)
Gamanuma,M., Cell. Signal. 15 (6), 565-574 (2003)
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