|Application ||WB, IHC-P, E|
|Calculated MW||54848 Da|
|Other Names||Fatty aldehyde dehydrogenase, Aldehyde dehydrogenase 10, Aldehyde dehydrogenase family 3 member A2, Microsomal aldehyde dehydrogenase, ALDH3A2, ALDH10, FALDH|
|Target/Specificity||This ALDH3A2 antibody is generated from rabbits immunized with human ALDH3A2 recombinant protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDH3A2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome.
Chang, C., et al., Genomics 40(1):80-85 (1997).
Rogers, G.R., et al., Genomics 39(2):127-135 (1997).
De Laurenzi, V., et al., Nat. Genet. 12(1):52-57 (1996).
Rogers, G.R., et al., Am. J. Hum. Genet. 57(5):1123-1129 (1995).
Pigg, M., et al., Nat. Genet. 8(4):361-364 (1994).
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