|Application ||WB, IHC-P, E|
|Calculated MW||57215 Da|
|Antigen Region||368-398 aa|
|Other Names||Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase, ALDH5A1, SSADH|
|Target/Specificity||This ALDH5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-398 amino acids from the C-terminal region of human ALDH5A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALDH5A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).|
|Tissue Location||Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ALDH5A1 belongs to the aldehyde dehydrogenase family of proteins. This protein functions as a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties.
Knerr,I., J. Inherit. Metab. Dis. 30 (3), 279-294 (2007)
Blasi,P., J. Mol. Evol. 63 (1), 54-68 (2006)
Plomin,R., Mol. Psychiatry 9 (6), 582-586 (2004)
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