|Application ||WB, IHC-P, E|
|Other Accession||Q8K2F8, Q3MHF8, NP_001107565.1, NP_056393.2|
|Calculated MW||50530 Da|
|Antigen Region||311-340 aa|
|Other Names||Protein LSM14 homolog A, Protein FAM61A, Protein SCD6 homolog, Putative alpha-synuclein-binding protein, AlphaSNBP, RNA-associated protein 55A, hRAP55, hRAP55A, LSM14A, C19orf13, FAM61A, RAP55, RAP55A|
|Target/Specificity||This LSM14A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 amino acids from the C-terminal region of human LSM14A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LSM14A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C19orf13, FAM61A, RAP55, RAP55A|
|Function||Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.|
|Cellular Location||Cytoplasm. Cytoplasm, P-body. Note=Targeted to stress granules (SGs) in response to cellular stress|
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Provided below are standard protocols that you may find useful for product applications.
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.
Marnef, A., et al. Int. J. Biochem. Cell Biol. 41(5):977-981(2009)
Tanaka, K.J., et al. J. Biol. Chem. 281(52):40096-40106(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Yang, W.H., et al. RNA 12(4):547-554(2006)
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