|Application ||WB, E|
|Other Accession||NP_002555.2, NP_788086.1, NP_788085.1|
|Calculated MW||42273 Da|
|Antigen Region||324-352 aa|
|Other Names||P2Y purinoceptor 2, P2Y2, ATP receptor, P2U purinoceptor 1, P2U1, P2U receptor 1, Purinergic receptor, P2RY2, P2RU1|
|Target/Specificity||This P2RY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-352 amino acids from the C-terminal region of human P2RY2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2RY2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Spleen, testis, kidney, liver, lung, heart and brain|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Boucher, I., et al. Am. J. Physiol., Cell Physiol. 299 (2), C411-C421 (2010) :
Ratchford, A.M., et al. J. Biol. Chem. 285(10):7545-7555(2010)
Taboubi, S., et al. Mol. Biol. Cell 21(6):946-955(2010)
Vazquez-Cuevas, F.G., et al. Reprod. Biol. Endocrinol. 8, 88 (2010) :
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